Recognize the optimal Neoadjuvant treatment for muscle-invasive bladder cancer

A 60-year-old man, who is a non-smoker, presents to the urology clinic for evaluation of painless gross hematuria. His medical history is not significant. Physical exam is normal. CT scan of the abdomen and pelvis shows a calcified bladder mass with no other abnormality. Cystoscopy and TURBT reveal a 3-cm high-grade papillary urothelial carcinoma. There is invasion of muscularis propria. The patient is planned to undergo radical cystoscopy.


Which of the given is the best additional management?